Increased Cytokine Production in Interleukin-18 Receptor -deficient Cells Is Associated with Dysregulation of Suppressors of Cytokine Signaling*
نویسندگان
چکیده
Claudia A. Nold-Petry, Marcel F. Nold, Jason W. Nielsen, Alex Bustamante, Jarod A. Zepp, Kathleen A. Storm, Jae-Woo Hong, Soo-Hyun Kim, and Charles A. Dinarello From the Department of Medicine, University of Colorado Denver, Aurora, Colorado 80045, Source Molecular Diagnostics, Inc., Boulder, Colorado 80301, and the Department of Biomedical Science and Technology, Konkuk University, Seoul 143-701, Korea
منابع مشابه
Increased cytokine production in interleukin-18 receptor alpha-deficient cells is associated with dysregulation of suppressors of cytokine signaling.
Since interleukin (IL)-18 is a proinflammatory cytokine, mice lacking IL-18 or its ligand-binding receptor (IL-18R) should exhibit decreased cytokine and chemokine production. Indeed, production of IL-1alpha, IL-6, and MIP-1alpha was reduced in IL-18 knock-out (ko) mouse embryonic fibroblast (MEF)-like cells. Unexpectedly, we observed a paradoxical 10-fold increase in IL-1beta-induced IL-6 prod...
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